Side-by-side cost of living comparison for 2026
St. Louis and Syracuse have very similar costs of living, with less than a 3% difference overall.
Index values shown. National average = 100. Lower is cheaper.
To maintain the same standard of living:
See exact take-home pay: Missouri salaries · New York salaries
Housing is typically the biggest factor in any cost-of-living comparison. St. Louis has a housing index of 72 while Syracuse sits at 69 (national average = 100). The median home in St. Louis costs $175,000 compared to $140,000 in Syracuse, a difference of $35,000. Monthly rent follows a similar pattern: $1,000 in St. Louis versus $950 in Syracuse.
Groceries and everyday expenses show a narrower gap: St. Louis scores 97 while Syracuse scores 101. Both cities are close to the national average for grocery costs.
Healthcare costs in St. Louis (95) are lower than Syracuse (100). Both are close to the national average.
Median household income in St. Louis is $45,782 compared to $36,708 in Syracuse. When adjusted for cost of living, purchasing power is similar in both cities.
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