Side-by-side cost of living comparison for 2026
Greenville and Sioux Falls have very similar costs of living, with less than a 3% difference overall.
Index values shown. National average = 100. Lower is cheaper.
To maintain the same standard of living:
See exact take-home pay: South Carolina salaries · South Dakota salaries
Housing is typically the biggest factor in any cost-of-living comparison. Greenville has a housing index of 85 while Sioux Falls sits at 80 (national average = 100). The median home in Greenville costs $250,000 compared to $265,000 in Sioux Falls, a difference of $15,000. Monthly rent follows a similar pattern: $1,200 in Greenville versus $1,100 in Sioux Falls.
Groceries and everyday expenses show a narrower gap: Greenville scores 98 while Sioux Falls scores 97. Both cities are close to the national average for grocery costs.
Healthcare costs in Greenville (103) are higher than Sioux Falls (101). Both are close to the national average.
Median household income in Greenville is $48,912 compared to $61,714 in Sioux Falls. When adjusted for cost of living, purchasing power is similar in both cities.
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