Side-by-side cost of living comparison for 2026
4% cheaper
Greenville is 4% more affordable than Mesa. A $75,000 salary in Mesa is equivalent to $71,970 in Greenville.
Index values shown. National average = 100. Lower is cheaper.
To maintain the same standard of living:
See exact take-home pay: South Carolina salaries · Arizona salaries
Housing is typically the biggest factor in any cost-of-living comparison. Greenville has a housing index of 85 while Mesa sits at 98 (national average = 100). The median home in Greenville costs $250,000 compared to $350,000 in Mesa, a difference of $100,000. Monthly rent follows a similar pattern: $1,200 in Greenville versus $1,350 in Mesa.
Groceries and everyday expenses show a narrower gap: Greenville scores 98 while Mesa scores 99. Both cities are close to the national average for grocery costs.
Healthcare costs in Greenville (103) are higher than Mesa (95). Both are close to the national average.
Median household income in Greenville is $48,912 compared to $60,234 in Mesa. When adjusted for cost of living, income goes further in Greenville.
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