Side-by-side cost of living comparison for 2026
24% cheaper
Des Moines is 24% more affordable than Santa Fe. A $75,000 salary in Santa Fe is equivalent to $57,051 in Des Moines.
Index values shown. National average = 100. Lower is cheaper.
To maintain the same standard of living:
See exact take-home pay: Iowa salaries · New Mexico salaries
Housing is typically the biggest factor in any cost-of-living comparison. Des Moines has a housing index of 74 while Santa Fe sits at 153 (national average = 100). The median home in Des Moines costs $210,000 compared to $480,000 in Santa Fe, a difference of $270,000. Monthly rent follows a similar pattern: $1,100 in Des Moines versus $1,600 in Santa Fe.
Groceries and everyday expenses show a notable difference: Des Moines scores 96 while Santa Fe scores 103. Both cities are close to the national average for grocery costs.
Healthcare costs in Des Moines (97) are higher than Santa Fe (95). Both are close to the national average.
Median household income in Des Moines is $55,958 compared to $61,982 in Santa Fe. When adjusted for cost of living, income goes further in Des Moines.
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