Side-by-side cost of living comparison for 2026
49% cheaper
St. Louis is 49% more affordable than Cambridge. A $75,000 salary in Cambridge is equivalent to $37,921 in St. Louis.
Index values shown. National average = 100. Lower is cheaper.
To maintain the same standard of living:
See exact take-home pay: Massachusetts salaries · Missouri salaries
Housing is typically the biggest factor in any cost-of-living comparison. Cambridge has a housing index of 280 while St. Louis sits at 72 (national average = 100). The median home in Cambridge costs $890,000 compared to $175,000 in St. Louis, a difference of $715,000. Monthly rent follows a similar pattern: $3,100 in Cambridge versus $1,000 in St. Louis.
Groceries and everyday expenses show a notable difference: Cambridge scores 110 while St. Louis scores 97.
Healthcare costs in Cambridge (118) are higher than St. Louis (95).
Median household income in Cambridge is $103,154 compared to $45,782 in St. Louis. When adjusted for cost of living, income goes further in St. Louis.
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